Can I use a SATA drive in a SAS machine? June 6, 2018 18 A Can I use a SATA drive in a SAS machine? This will depend on the machine. Some machines take one or the other, but some machines are capable of working with both drive types. Category: Hard Drives and Accessories Back to Top GET THE LATEST NEWS IN YOUR INBOX Don't worry we don't spam - EVER PreviousWhat is the difference in SATA and SAS? NextWhat is a MUX board?